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This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]

However, men can and do experience cellulite (some estimates state this can be around 10% of men)

DPP4 have demonstrated anti hyperglycemic efficacy of DPP4 inhibitors alone or in combination, with mean change in Hb1ac-3 to -19 mmol/mol (-0.3 to -1.7%) without excess risk of hypoglycemia or weight gain (Figure 2)

In PCOS, it improves insulin sensitivity, supports ovulatory function, modulates hepatic and ovarian gene expression, and influences gut microbiota

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