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For those with significant obesity, referral to a Tier 3 specialist weight-management service or, where clinically appropriate, consideration of bariatric surgery under Tier 4 criteria may be appropriate

Each of these conditions tends to improve as weight comes down, which is a big part of the clinical case for treating them together

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In auto-immune diseases, signaling of NF-kB is stuck in the ON position leading to cellular destruction, increased cytokine levels and more