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Taking too little may not show results, while overdosing unnecessarily wont offer extra benefits

While Mounjaro was studied primarily in people with type 2 diabetes, some of the strongest evidence for tirzepatide's weight-loss effects comes from dedicated obesity trials

A patient with a GLP1R variant suggesting lower receptor sensitivity might benefit from early consideration of tirzepatide (dual action) rather than semaglutide alone

PubMed pubmed.ncbi.nlm.nih.gov [41] Semaglutide for the treatment of obesity PubMed pubmed.ncbi.nlm.nih.gov [42] Role of GLP-1 Receptor Agonists in Pediatric Obesity: Benefits, Risks, and Approaches to Patient Selection PubMed pubmed.ncbi.nlm.nih.gov [43] The Antiobesity Effect and Safety of GLP-1 Receptor Agonist in Overweight/Obese Adolescents Without Diabetes Mellitus: A Systematic Review and Meta-Analysis PubMed pubmed.ncbi.nlm.nih.gov [44] A cost comparison of GLP-1 receptor agonists and bariatric surgery: what is the break even point

GLP-1 therapies also help improve blood sugar control