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Recent reviews by these agencies have found no evidence of a causal association between GLP-1 receptor agonists and suicidal thoughts or self-harm, though vigilance continues

However, metformin offers minimal appetite suppression, which limits its usefulness as a standalone weight loss tool for patients without diabetes

As a weight loss approach, Glp-1 agonists further slow down the metabolism to control blood sugar

Can Res 63(18):59405949 Kim HJ, Han MH, Kim GY, Choi Y-W, Choi YH (2012) Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells