If you have a methylation issue then you will want to use methylcobalamin
A clinical series published in the Journal of Clinical Medicine found that patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) who received intermittent intravenous saline infusions over a 9-week period showed beneficial effects in managing symptoms of dysautonomia and postural orthostatic tachycardia syndrome (POTS)
On July 23, 2026, an FDA advisory committee voted 86 with one abstention to recommend adding it to the 503A bulks list
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Yatsuhashi, H., Furuyashiki, T., Thi Vo, P