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Research conducted in one population may not apply to different cultural contexts, limiting the generalizability of current findings

,, Although there are several inhibitors of the cystine/glutamate transporter other than sulfasalazine, these drugs have limitations of low bioavailability and low selectivity to of the cystine/glutamate transporter in vivo

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ADDITIONAL RESEARCH & SCIENTIFIC DATA

Metabolism of Oltipraz Metabolism of OPZ results in the production of a minor oxo analog (2), and the major dimethylated pyrrolopyrazine (3) through the biological methylation of the intermediate pyrrolopyrazine thione (4).