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Debunking Common Myths About Glutathione Glutathione benefits skin through two primary biological pathways: first, as a potent antioxidant it neutralizes oxidative stress triggered by pollution, UV exposure, and environmental inflammation, factors known to accelerate skin aging by degrading collagen and elastin fibres and weakening the skin barrier, which leads to loss of skin firmness and elasticity

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Of late, multiple transcription factors such as TFAP2C, p53, AP-1, STAT, Nrf2, HIF-1, and C/EBP have been linked with the transcriptional regulation of seleno-GPxs [8, 21,22,23,24]