In 1980 Jean-Pierre Raufman, a young gastroenterologist (figure 33), and John Pisano, a biochemist at the National Institute of Health with a fascination for venoms, began investigating the effect of peptides found in the saliva of the lizard on human physiology
It involves the competitive binding of labeled and non-labeled antigens to their specific antibodies, allowing sufficient time for the reaction to reach equilibrium
Obesity leads to chronic inflammation, he said, and that inflammation has very clear effects on your arteries and your cardiovascular system. Reducing that inflammation with GLP-1s, it turns out, reduces cardiovascular risk
Mistake 6: Injecting into the wrong tissue layer GLP-1 medications are designed for subcutaneous injection, meaning into the fat layer between the skin and the muscle
Historically, route of administration decisions have been made later in development, with many innovators opting for providing drugs in vials in order to reduce drug/device development complexity, says Brian Galliher, Principal Process Engineer, Catalent Biologics
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