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The GAPDH Ct value for various markers investigated by qPCR in the in vitro neuronal cells exposed to OGD following treatment with exendin-4 or semaglutide, and in combination with exendin-9: HIF-1- ( n = 6 for all experimental group), ATF-3 ( n = 3 for all experimental groups), Bcl-2 ( n = 6 for all experimental groups), Bcl-xL ( n = 4 for all experimental groups) and CREB ( n = 6 for all experimental groups)

194 The interaction by which p53 activates MDM2 and regulates the expression of negative p53 regulators occurs in the p53-MDM2 negative feedback loop

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Because of this dual action, it may give stronger signals for reduced hunger, improved insulin sensitivity, and greater fat loss