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Lazou K, Sadick NS, Kurfurst R, et al

Data availability Data sharing is not applicable to this article as no new data were created or analyzed in this study

Indeed, it was recently demonstrated that the pentose phosphate pathway (PPP), a major contributor of NADPH for the maintenance of glutathione in its reduced state, is critical for NRF2-induced proliferation [58, 59]

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Future research directions and challenges Development of new derivatives Local delivery system: study the complex of IGF 1 LR3 1mg and hydrogel or nanoparticles to achieve targeted release and reduce systemic side effects