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Methods A comprehensive literature review of PubMed, Embase, and Elsevier databases identified 17 relevant studies published between 2013 and 2024 that investigated the role of GLP-1 receptor agonists in bone metabolism, wound healing, and orthopedic surgery

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References 1.FDA Drug Safety Communication: FDA Investigating Reports of Possible Increased Risk of Pancreatitis and Pre-Cancerous Findings of the Pancreas from Incretin Mimetic Drugs for Type 2 Diabetes

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Rowe first suggested that mutations in Pkd1 result in a defective glucose metabolism with decreased gluconeogenesis and increased aerobic glycolysis to supply energy and promote proliferation (Rowe et al., 2013, Figure 1)