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The Foundation: Alpha-MSH and the Melanocortin System Before we can truly appreciate the differences between MT1 and MT2, we need a quick refresher on the system theyre designed to influence: the melanocortin system

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Zinc deficiency exacerbates these processes by upregulating molecules like vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), facilitating monocyte attachment and intensifying vascular inflammation and AS progression [475, 476]