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Factors including baseline insulin secretion capacity, duration of diabetes, prior medication exposure, and genetic variation in GLP-1 receptor expression influence individual response magnitude and timeliness

More recent studies have defined conditions that greatly improve the functional maturation of cells, achieving first- and second-phase insulin secretion[57,58]

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In a subgroup analysis of the effectiveness of orally administered semaglutide in a real-world setting, persistence on drug was associated with a significantly greater reduction in HbA1c [38]