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Some patients experience palpitations, a fluttering sensation in the chest, or feelings of nervousness and shakiness

Across these trials, tirzepatide delivered dose-dependent improvements in glycemic control and body weight, often surpassing comparators like semaglutide and dulaglutide (43)(44)

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Therefore, the two crucial mechanisms are that the transduction of PAR polymer to mitochondrial and the transfer of AIF from mitochondrial to nucleus to degrade chromatin