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Head-to-head comparison (STEP 8) The STEP 8 trial provides direct side-effect comparison data: 1 Gastrointestinal adverse events: 84.1% with semaglutide vs 82.7% with liraglutide Treatment discontinuation due to adverse events: 13.5% with semaglutide vs 27.6% with liraglutide While the overall rate of gastrointestinal side effects was similar, liraglutide had a substantially higher discontinuation rate

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