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Low levels of glutathione are also associated with chronic exposure to chemical toxins and alcohol, cadmium exposure, smoking, AIDS/HIV, macular degeneration, Parkinsons disease, and other neurodegenerative disorders

Protective effects of various otoprotectant molecules on cisplatin-induced degeneration of hair cells and spiral ganglion neurons were measured.FIGS

Furthermore, elevated cytosolic aconitase (c-ACNT) and isocitrate dehydrogenase (ICD2), synergistically enhanced by iron accumulation, drive citrate flux toward NADPH and -KG generation, thereby exacerbating intracellular citrate depletion

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