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The human microbiome, especially the gut microbiota, comprises numerous symbiotic bacterial species (e.g., Lactobacillus , Bacillus , Clostridium , Enterococcus , and Ruminococcus ) that collectively represent approximately 90% of the gut flora (Rinninella et al., 2019

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7C), suggesting an adaptive improvement in insulin sensitivity for maintenance of glucose homeostasis