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trial, subjects receiving weekly doses of 30 to 60 mcg/kg (roughly 2,000 to 4,000 mcg for an 80 kg adult) showed sustained IGF-1 elevation with no serious adverse events over the study period (Teichman et al., J Clin Endocrinol Metab 2006)
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ApoE4 alters ABCA1 membrane trafficking in astrocytes
Compared to MK-677 (Ibutamoren, non-peptide oral secretagogue), Ipamorelin presents a more physiological pulsatile kinetics (peak-return-peak) versus MK-677 which produces a sustained non-pulsatile elevation that may desensitize the receptor long-term
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