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The 3D structures of the homologous Mn and Fe superoxide dismutases have the same arrangement of alpha-helices, and their active sites contain the same type and arrangement of amino acid side-chains

Upon exposure to OGD/R, SH-SY5Y cells exhibited a marked upregulation of the proapoptotic proteins, Bax and caspase-3

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of these, it is generally believed that excited-state quenchers, peroxide decomposers, and radical scavengers are the most effective