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Availability of -alanine primarily limits carnosine synthesis by carnosine synthetase in human skeletal muscle and the olfactory bulb, but adequate provision of histidine in diets is also critical for maximal production of carnosine because histidine is not synthesized de novo (Hill et al

Thus, abnormalities in CNS insulin signaling pathways may inhibit A clearance, increasing neurotoxicity and promoting AD

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