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These sensations may extend up the arm and, in severe cases, can even lead to muscle atrophy or thinning of muscle mass in the thumb

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[11] Structure [edit] Mammalian GPX1, GPX2, GPX3, and GPX4 (this protein) have been shown to be selenium-containing enzymes, whereas GPX6 is a selenoprotein in humans with cysteine-containing homologues in rodents

In terms of pharmacological properties, DON and BPTES show moderate potency, poor metabolic stability, low water solubility, and limited selectivity for GLS, resulting in inferior antitumor efficacy compared to CB-839 (246, 247)

Providers should assess baseline bowel function, medication history, and comorbidities before recommending specific interventions