Other Side Effects Muscle pain (due to fasciculations) Increased intragastric pressure aspiration risk Increased intraocular pressure (contraindicated in glaucoma) Pharmacokinetics Routes: IV or IM Rapid metabolism by plasma pseudocholinesterase Not metabolized by acetylcholinesterase Key Parameters: Onset: 3060 seconds Duration: 610 minutes Half-life: 35 minutes Notes: Phase II block recovery may last 30 minutes or longer Duration depends on: Rate of receptor dissociation Plasma enzyme activity Drug Interactions Increase Duration of Action: Cholinesterase inhibitors (e.g., neostigmine , pyridostigmine ) Administration of neostigmine & pyridostigmine to patients to reverse non-depolarizing skeletal muscle blockade has been shown to cause profound reductions of plasma pseudocholinesterase activity for several hours duration (Mirakhur et al, 1982), an effect that can mechanistically account for the observed prolongation of succinylcholine effect by these cholinesterase inhibitors (Sunew & Hicks, 1978
Broccoli sprouts have between 10-100 times more Glucoraphanin than mature broccoli heads
B., Yogesh Kumar K., et al., Synthesis, Molecular Docking, Enzyme Inhibition and Antioxidant Potential of New 1HBenzo[d]Imidazole5Carboxamide Derivatives, Journal of Molecular Structure 1302 (2024): 137521, 10.1016/j.molstruc.2024.137521
J Int Med Res 2005;33(3):267-272
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