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Sometimes behavioral regression occurs. The regression of skills might be as subtle as first having a social smile and playfulness at 6 to 8 months of age and then losing these skills

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These more serious effects are generally linked to specific risk factors such as overdose, pre-existing respiratory conditions, or concomitant use of other central nervous system depressants rather than standard therapeutic use

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Neuroreport (2008) 19(13):13358.10.1097/WNR.0b013e32830b8afa 82 LinYDesboisAJiangSHouST

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